Hepatitis B Virus X Gene Differentially Modulates Subgenotype F1b and F4 Replication
نویسندگان
چکیده
منابع مشابه
Mutations at Nucleotide 1762, 1764 and 1766 of Hepatitis B Virus X Gene in Patients with Chronic Hepatitis B and Hepatitis B-Related Cirrhosis
Abstract Background and objective: Hepatitis B virus (HBV) is a DNA virus with high tendency toward hepatic tissue. There are currently about 3 million HBV-infected people and 350 to 400 million chronic carriers of this virus in the world. X protein plays a role in the over-expression of oncogenes, carcinogenicity of liver cells and overlaps with the basal co...
متن کاملHepatitis B virus X protein modulates remodelling of minichromosomes related to hepatitis B virus replication in HepG2 cells.
Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is organised into minichromosomes by histone and non-histone proteins. Remodelling of minichromosomes is crucial for the regulation of HBV replication, which is dependent on the presence of the hepatitis B virus X protein (HBx). However, the mechanisms of HBx-dependent HBV replication...
متن کاملSubgenotype reclassification of genotype B hepatitis B virus
BACKGROUND Nine subgenotypes from genotype B have been identified for hepatitis B virus (HBV). However, these subgenotypes were less conclusive as they were often designated based on a few representative strains. In addition, subgenotype B6 was designated twice for viruses of different origin. METHODS All complete genome sequences of genotype B HBV were phylogenetically analyzed. Sequence div...
متن کاملThe hepatitis B virus X protein modulates hepatocyte proliferation pathways to stimulate viral replication.
Worldwide, there are over 350 million people who are chronically infected with the human hepatitis B virus (HBV); chronic HBV infections are associated with the development of hepatocellular carcinoma (HCC). The results of various studies suggest that the HBV X protein (HBx) has a role in the development of HBV-associated HCC. HBx can regulate numerous cellular signal transduction pathways, inc...
متن کاملrpb۵-mediating protein suppresses hepatitis b virus (hbv) transcription and replication by counteracting the transcriptional activation of hepatitis b virus x protein in hbv replication mouse model
conclusions our study demonstrated that a low dose of rmp could inhibit hbv transcription and replication, which is dependent on the appearance of hbx in vivo. results rpb5-mediating protein could inhibit hbv transcription and replication in groups transfected with the 1.2 wt and hbx. the inhibitory effect disappeared in the 1.2x (-) groups, yet it reappeared in the groups co-transfected with 1...
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ژورنال
عنوان ژورنال: Viruses
سال: 2019
ISSN: 1999-4915
DOI: 10.3390/v11070655